Stage 2: Research & Development
The primary objective is to assess the sensitivity and specificity of detection rats as a triage tool compared to GeneXpert as the reference standard. The secondary objective is to determine the yield of the total screening algorithm when GeneXpert is used as the confirmatory diagnostic test.
Registered In Mozambique.
Health and Infectious & Vector Diseases
Health and Infectious & Vector DiseasesSEE LESS
Mozambique and Tanzania
Mozambique and TanzaniaSEE LESS
Countries Implemented In
Funds Raised to Date
APOPO uses trained African Giant Pouched Rats, nicknamed “HeroRATs,” to detect tuberculosis (TB) by scent in clinical samples in Tanzania and Mozambique.APOPO is assessing the sensitivity, specificity, and cost-effectiveness of detection rats as a triage tool when paired with GeneXpert, a highly accurate but relatively expensive DNA diagnostic tool endorsed by the World Health Organization.
How does your innovation work?
The results from this study will be used to determine the cost-effectiveness of detection rats as a triage tool. We hypothesize that TB detection rats are a very cost-effective diagnostic tool, given their evaluation speed, the low evaluation and maintenance costs, and their promising diagnostic accuracy.
Planned Goals and Milestones
We propose a oneyear multisite study in Tanzania and Mozambique, in which 2,500 prison inmates, new entrants and remandees of prisons located in the respective countries will be examined for TB. The cost-effectiveness of a screening algorithm including TB detection rats as a triage tool will be rigorously assessed alongside the proposed project by using decision analytic modeling. Preliminary findings confirm that TB detection rats indeed are more cost-effective than competing triage tools.